Effects of TJ-35 (Shigyaku-san) on Gastric Mucosal Injury Induced by Ischemia-Reperfusion and Its Oxygen-Derived Free Radical-Scavenging Activities
| Autor: | Yuji Naito, Hirohisa Takano, Naohiro Tasaki, Motoharu Rondo, Toshikazu Yoshikawa, Shuji Takahashi, Mitsunori Yasuda, Hiroshi Ichikawa, Toru Tanigawa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty Nutrition and Dietetics Spin trapping Superoxide Clinical Biochemistry Mucosal lesions Ischemia Medicine (miscellaneous) chemistry.chemical_element Pharmacology medicine.disease Oxygen In vitro Lipid peroxidation chemistry.chemical_compound chemistry Oral administration medicine |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition. 10:189-196 |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.10.189 |
| Popis: | We investigated the effects of TJ-35 (Shigyaku-san) on gastric mucosal injury induced by ischemia-reperfusion in rats; and using the electron spin resonance (ESR) spin trapping method, we also assessed its oxygen-derived free radical-scavenging activities. The increase in mucosal lesions and in thiobarbituric acid-reactive substances (as an index of lipid peroxidation) was significantly inhibited by the oral administration of 500mg/kg of TJ-35; and in addition, TJ-35 demonstrated superoxide and hydroxyl radical-scavenging activities in vitro. These results suggest the possibility that the effects of TJ-35 on gastric mucosal injury induced by ischemia-reperfusion may be the result of its free radical-scavenging activities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|