Lärminduzierte Neurodegeneration der zentralen Hörbahn
| Autor: | D. Basta, A. Ernst, M. Gröschel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
business.industry Hearing loss Thalamus Central nervous system Auditory cortex medicine.disease 03 medical and health sciences Noise 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology Cortex (anatomy) Medicine Auditory system medicine.symptom business Neuroscience 030217 neurology & neurosurgery Noise-induced hearing loss |
| Zdroj: | HNO. 66:258-264 |
| ISSN: | 1433-0458 0017-6192 |
| DOI: | 10.1007/s00106-018-0485-6 |
| Popis: | Background A noise trauma induces central nervous system pathologies, which generate deficits in hearing and perception of sound. Objective Are degenerative mechanisms in the central auditory system a direct impact of overstimulation or an effect of acoustic deprivation? Materials and methods Detection of cell death in a mouse model of noise-induced hearing loss at different times after single or repeated noise exposure. Results A single noise exposure (3 h, 115 dB SPL, 5-20 kHz) induces acute (≤1 day) and long-term (observation period 14 days) degeneration, particularly in subcortical structures. Repeated noise trauma is followed by pathologies in the auditory thalamus and cortex. Conclusion Noise has a direct impact on basal structures of the central auditory system; a protection of cortical areas is possibly due to inhibitory neuronal projections. Degenerative mechanisms in higher structures of the pre-damaged system point to an increased impairment of complex processing of acoustic information. |
| Databáze: | OpenAIRE |
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