Labeling of PKC412 - a fermentative radiolabeling

Autor:	Th. Moenius, P. Burtscher, H. Haecker
Rok vydání:	2010
Předmět:	Chemistry Stereochemistry Organic Chemistry Drug Discovery medicine Staurosporine Radiology Nuclear Medicine and imaging Fermentation broth Biochemistry Spectroscopy Analytical Chemistry medicine.drug
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 53:613-615
ISSN:	0362-4803
DOI:	10.1002/jlcr.1792
Popis:	Addition of [3-14C]D/L-tryptophan to the fermentation broth allowed radiofermentative labeling of staurosporine. The approach providing [4c,7a-14C2]staurosporine in a range from 700 to 1300 MBq/mmol was straightforward and easy to handle as well as safe from a radioprotection point of view. The presented example underlines that close cooperation of microbiologists and radiochemists is a requisite for the success of this approach. Copyright © 2010 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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