Synthesis and characterization of degraded gelatin grafted poly(ɛ-caprolactone) copolymers
| Autor: | Heyun Wang, Zichen Fang, Yakai Feng, Jintang Guo |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Multidisciplinary
food.ingredient Biocompatibility technology industry and agriculture macromolecular substances musculoskeletal system equipment and supplies Grafting Gelatin Isocyanate chemistry.chemical_compound End-group food chemistry Polymerization Polymer chemistry Copolymer Isophorone diisocyanate |
| Zdroj: | Transactions of Tianjin University. 19:182-187 |
| ISSN: | 1995-8196 1006-4982 |
| DOI: | 10.1007/s12209-013-1947-2 |
| Popis: | Hydrophilic degraded gelatin was modified with hydrophobic poly(ɛ-caprolactone) (PCL) via a chemical grafting route. Firstly, PCL with one hydroxyl end group was prepared by the ring-opening polymerization of ɛ-caprolactone (ɛ-CL) with tin (II) 2-ethylhexanoate as catalyst and n-butyl alcohol as initiator. Secondly, the PCL reacted with isophorone diisocyanate (IPDI) to prepare PCL with isocyanate functional group (PCL-NCO). Hydroxylamine was used to degrade gelatin by the cleavage between asparagine and glycine residues of gelatin. PCL-NCO reacted with the hydroxyl/amino groups of degraded gelatin in a homogeneous system and yielded the PCL modified gelatin copolymers. The gelatin grafted PCL copolymers were measured by means of XRD, FTIR, DSC and 1H NMR. The results confirmed the conjugation of PCL onto gelatin chains. The PCL modified gelatin can be used as biomaterials owing to their biocompatibility and biodegradation. |
| Databáze: | OpenAIRE |
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