Synthesis of Chiral Prostaglandin (Pge2) Via Stork Intermediate By Using Vinylzincates For Conjugate Addition1)

Autor:	Makoto Nakazawa, Takashi Takahashi, Keiji Yamamoto, Kazuhiko Takatori, Seijiro Nishimura
Rok vydání:	1993
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Formaldehyde Enantioselective synthesis Molecular Medicine chemistry.chemical_element Prostaglandin Ether Lithium Derivative (chemistry) Conjugate
Zdroj:	Natural Product Letters. 1:263-267
ISSN:	1057-5634
Popis:	We report here the synthesis of chiral PGE2 methyl ester as a bissilyl ether via Stork intermediate, which involves the conjugate addition of lithium (E)-vinyldimethylzincate to 4-t-butyldimethylsiloxy-2-cyciopentenone followed by the formaldehyde trapping of the kinetic enolate to give eventually rise to a 2-methylenecyclopentanone derivative, the latter being subjected to the conjugate addition of another (Z)-vinylzincate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::da6fb70a2b1db26205eb8a54f369122e https://doi.org/10.1080/10575639308050058 Zobrazit plný text záznamu