Biodistribution evaluation of 166Ho–DTPA–SPION in normal rats
| Autor: | Saeed Shanehsazzadeh, Amir Gholami, Amir Reza Jalilian, Reza Haji Hosseini, Hassan Yousefnia, Afsaneh Lahooti, Sahar Nosrati, Cordula Grüttner |
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| Rok vydání: | 2015 |
| Předmět: |
Biodistribution
Health Toxicology and Mutagenesis Spleen 010403 inorganic & nuclear chemistry 01 natural sciences 030218 nuclear medicine & medical imaging Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Negative Contrast Agent medicine Radiology Nuclear Medicine and imaging Spectroscopy medicine.diagnostic_test business.industry Radiochemistry Public Health Environmental and Occupational Health Magnetic resonance imaging Mononuclear phagocyte system Pollution 0104 chemical sciences medicine.anatomical_structure Dextran Nuclear Energy and Engineering chemistry Nuclear medicine business Iron oxide nanoparticles |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 307:1559-1566 |
| ISSN: | 1588-2780 0236-5731 |
| Popis: | Super paramagnetic iron oxide nanoparticles (SPION) with a cross-linked dextran coating can be used as a negative contrast agent in magnetic resonance imaging agent. This study describes the preparation, biodistribution of 166Ho–DTPA–SPIONs after intravenous injection in normal Wistar rats. The biodistribution of 166Ho–DTPA–SPIONs showed dramatic uptake in reticuloendothelial system (i.e., more than 60 and 15 % of injected dose was in liver and spleen at 30 min post-injection, respectively) and the clearance of the radiotracer is so fast in other organs. These results suggest that 166Ho–DTPA–SPIONs could be good candidate for theranostic purposes in for liver and spleen malignancies. |
| Databáze: | OpenAIRE |
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