| Autor: |
V. R. Sinha, Amita Sarwal, Tamas Sohajda, Rajesh Kumar, Lalita Dahiya |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-422160/v1 |
| Popis: |
Aim of the study was to develop optimised drug-in-adhesive (DIA) transdermal patch of duloxetine HCl. It is known that acrylic polymers having different functional groups play significant role in enhancing drug permeation. Among various permeation enhancers (PEs), Transcutol P exhibited most enhanced permeation (ER≈1.99) in terms of flux and Q24 compared to control group having no PE. Hence, a transdermal DIA patch having DURO-TAK 87-2287 as DIA polymer and TP as PE loaded with 40% DLX previously complexed with MeβCD and duly characterised (FTIR, DSC and SEM) was developed for in vivo study. Mean of maximum plasma concentration (Cmax) and area under time-concentration curve (AUC0-72) in Wistar rats (n=6) for transdermal patch (10 mg/kg) was found to be 70.31±11.2 ng/ml and 2997.29±387.4 ng/ml*h respectively and these values were considerably higher than oral dose of DLX (20 mg/kg and 10 mg/kg). Albeit, T1/2 was higher in case of transdermal delivery but this was due to sustained behaviour of delivery system. These findings highlight the significance of both inclusion complexation and transdermal delivery of DLX using DIA patch for efficient drug absorption and thus reducing the dose of drug and related side effects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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