Sustained release nanofibrous composite patch for transdermal antibiotic delivery
| Autor: | Kosar Sadat Ebrahimi, Negin Farhadian, Najmeh Nematpour, Salar Khaledian, Sajad Moradi, Mohsen Shahlaei, Elham Arkan, Faranak Seyedi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Transdermal patch technology industry and agriculture 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Dermal patch 01 natural sciences Electrospinning 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry chemistry Nanofiber Polycaprolactone 0210 nano-technology Drug carrier Antibacterial agent Transdermal Biomedical engineering |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 586:124267 |
| ISSN: | 0927-7757 |
| Popis: | In this paper, Dextran, Polycaprolactone (PCL) and Graphene oxide (GO) were used to fabricate a nanofibrous transdermal patch by electrospinning for wound dressing. An antibacterial agent, tetracycline (TC) was incorporated in the composite patch. The physiochemical properties of the as-prepared nanofiber was evaluated using FTIR and SEM. Swelling index, mechanical characteristics and release profile were also examined. A uniform nanofibrous structure with 50 nm of diameter was obtained using 50 % w/w dextran loaded by TC@GO. The interior part of the patch included TC loaded GO embedded on the dextran nanofiber was protected from moisture penetration by a supplemental hydrophobic PCL layer. Besides, the later layer improves the mechanical properties of the composite. Also drug release study of nano fibrous drug carrier showed a controlled-sustained release pattern of TC for up to three days. Finally the nano dressing has shown a good antibacterial activity against both E. coli and S. aureus hence it could be used as dermal patch for treatment of chronic infectious lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect