A Practical Access to 1,2-Diaminophytosphingolipids

Autor: Youssef Harrak, Antonio Delgado, Amadeu Llebaria
Rok vydání: 2008
Předmět:
Zdroj: European Journal of Organic Chemistry. 2008:4647-4654
ISSN: 1099-0690
1434-193X
DOI: 10.1002/ejoc.200800565
Popis: A practical approach to the synthesis of phytosphingolipids containing the 1,2-diamino framework is described. The methodology relies on the regioselective ring-opening of phytosphingosine-derived N-nosylaziridines 4 and 6 with primary or secondary amines, acylation and subsequent deprotection steps. For practical purposes, N-substituted benzylamines were used as protected primary amine surrogates to avoid side-reactions in the course of the N-nosyl deprotection step.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Databáze: OpenAIRE