A Practical Access to 1,2-Diaminophytosphingolipids
Autor: | Youssef Harrak, Antonio Delgado, Amadeu Llebaria |
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Rok vydání: | 2008 |
Předmět: | |
Zdroj: | European Journal of Organic Chemistry. 2008:4647-4654 |
ISSN: | 1099-0690 1434-193X |
DOI: | 10.1002/ejoc.200800565 |
Popis: | A practical approach to the synthesis of phytosphingolipids containing the 1,2-diamino framework is described. The methodology relies on the regioselective ring-opening of phytosphingosine-derived N-nosylaziridines 4 and 6 with primary or secondary amines, acylation and subsequent deprotection steps. For practical purposes, N-substituted benzylamines were used as protected primary amine surrogates to avoid side-reactions in the course of the N-nosyl deprotection step.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) |
Databáze: | OpenAIRE |
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