A Novel β-Amino Acid in Cytotoxic Peptides from the CyanobacteriumTychonema sp

Autor:	Christian Mehner, Armin Maier, Reik Löser, Daniela Müller, Michael Gütschow, Gabriele M. König, Reto Brun, Stefan Kehraus, Anja Krick, Heinz-Herbert Fiebig
Rok vydání:	2008
Předmět:	chemistry.chemical_classification biology medicine.drug_class Organic Chemistry biology.organism_classification Amino acid Biochemistry chemistry Cancer cell Monolayer Trypanosoma Antiprotozoal medicine Cytotoxic T cell Physical and Theoretical Chemistry Clonogenic assay IC50
Zdroj:	European Journal of Organic Chemistry. 2008:1732-1739
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200701033
Popis:	The cyclic dodecapeptides tychonamide A (1) and B (2) isolated from the methanolic extract of the cyanobacterium Tychonema sp. contain the novel β-amino acid 3-amino-2,5,7-trihydroxy-8-phenyloctanoic acid (Atpoa). Compounds 1 and 2 have cytotoxic activity towards cancer cell linesin a monolayer assay with mean IC50 values of 0.9 and 3.3 μg mL–1, respectively. Compound 2 was shown to be active against tumor cell suspensions derived fromsolid tumor xenografts in a clonogenic assay (mean IC50 2.4 μg mL–1). Additionally, antiprotozoal activity was observed (Trypanosoma b. rhodesiense, IC50 0.1 μg mL–1) for compound 1. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Databáze:	OpenAIRE
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