| Autor: |
Matthew R. Palmer, John T. Goorley, Irving D. Kaplan, Lujia Tang, W. S. Kiger, Otto K. Harling, Guido R. Solares, Cynthia F. Chuang, Jody Kaplan, Robert G. Zamenhof, Kent J. Riley, Paul M. Busse |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
Frontiers in Neutron Capture Therapy ISBN: 9781461354789 |
| Popis: |
The clinical use of BNCT originated in Boston largely through the efforts of Dr. William Sweet at the Massachusetts General Hospital and his collaborators at the Brookhaven National Laboratory (BNL) and the Massachusetts Institute of Technology (MIT). The early clinical trials were for patients with primary brain tumors but were unsuccessful largely due to the poor biodistribution of 10B and thermal neutron beams that had limited penetration into tissue. Clinical and basic researchers recognized there would have to be a dramatic improvement in the amount of 10B delivered to a tumor as well as an improvement in the biodistribution, i.e., an increase in the tumor to normal tissue ratio, before clinical studies could be resumed. In addition, nuclear engineers and physicists realized epithermal beams needed to be developed that would obviate many of the physical limitations inherent in the thermal beams that had previously been used. The culmination of this multifaceted preclinical work in biology, physics, 10B quantification, treatment planning, and epithermal beam design was in September 1994 when the first human subject was irradiaied with epithcrmal nculton BNCT at the MIT Nuclear Reaclor Laboratory. This subject was irradiated to the plantar surface of the foot following the administration of oral p-boronophenylalanine (BPA); two weeks later another patient wiih glioblastoma received a single field of epithermal neutron irradiation al BNL, with iniravenously adminisiered BPA-fructose as a 10B carrier. Since then a number of clinical trials that are primarily phase I in natute have been conducted or are currently in progress at both insiitutions with epithermal neutton beams.1 Over 60 subjects have been irradiaied. the majority to the cranium for glioblasioma multiforme and in addition, 4 subjects have been irradiaied to 5 sites at MIT for melanoma of the extremity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
