Preparation by controlled radical polymerization and self-assembly via base-recognition of synthetic polymers bearing complementary nucleobases

Autor: Jean-François Lutz, Rainer Nehring, Andreas F. Thünemann
Rok vydání: 2005
Předmět:
Zdroj: Journal of Polymer Science Part A: Polymer Chemistry. 43:4805-4818
ISSN: 1099-0518
0887-624X
Popis: The radical polymerization of three monomers bearing nucleobases 1-(4- vinylbenzyl)thymine (VBT), 1-(4-vinylbenzyl)uracil (VBU) and 9-(4-vinylbenzyl)ade- nine (VBA) was investigated. The corresponding homopolymers could be prepared in high yields via conventional radical polymerization. However, the resulting polymers were found to be only soluble in a few polar solvents. On the other hand, copolymers of dodecyl methacrylate (DMA) with either VBT or VBA could be prepared via both free radical polymerization and atom transfer radical polymerization and could be dissolved in a large variety of organic solvents. Moreover, the formed complementary copolymers P(VBT-co-DMA) and P(VBA-co-DMA) were found to self-assemble in dilute solutions in dioxane or chloroform via base recognition, as evidenced by a sig- nificant hypochromicity effect in UV spectroscopy. Nevertheless, at higher concentra- tions in chloroform, both dynamic light scattering and optical microscopy indicate that P(VBT-co-DMA), P(VBA-co-DMA), or P(VBT-co-DMA)/P(VBA-co-DMA) mixtures spontaneously self-assemble into micron size spherical aggregates. 1 H NMR and FTIR studies confirmed that the self-assembly process is driven in all cases via H-bond for- mation. V C 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 4805-4818, 2005
Databáze: OpenAIRE
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