A modification of the asymmetric dihydroxylation approach to the synthesis of (S)-2-arylpropanoic acids

Autor:	Tae Kanai, Junko Yagi, Hiroyuki Ishibashi, Momoe Maeki, Masashi Ohba
Rok vydání:	1999
Předmět:	Hydrogenolysis Chemistry Dihydroxylation Organic Chemistry Drug Discovery Organic chemistry Optically active Biochemistry Catalysis
Zdroj:	Tetrahedron. 55:6075-6080
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(99)00279-3
Popis:	Catalytic hydrogenolysis of (S)-2-phenyl-1,2-propanediol (2), prepared by an asymmetric dihydroxylation of α-methylstyrene (1) with AD-mix-α, over Pearlman's catalyst gave (S)-2-phenyl-1-propanol (3). This method was applied to the synthesis of optically active 2-arylpropanoic acid anti-inflammatory agents, (S)-ibuprofen (8) and (S)-naproxen (13).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::da4918ae2d9a59635882f2fa68daea99 https://doi.org/10.1016/s0040-4020(99)00279-3 Zobrazit plný text záznamu Full Text from ScienceDirect