Accelerated progression of Hodgkin’s-like lymphoma in golli-deficient mice is associated with higher induction of CD4+FoxP3+ regulatory T cells (TUM9P.1018)
| Autor: | Ji-Ming Feng, Suidong Ouyang, Guangming Han |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 194:210.20-210.20 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | The spontaneously occurred lymphomas in SJL/J mice have many pathological features similar to Hodgkin’s lymphoma in human. The malignant growth of the tumor cells is dependent on the support of host FoxP3+ CD4+ regulatory T cells (Tregs). In this study, we report that the golli protein, a negative regulator of CRAC (calcium release activated calcium) channel in T cells, plays a critical role in the tumorigenesis of Hodgkin’s-like lymphoma. The ablation of golli protein in SJL/J mice results in an accelerated progression of Hodgkin’s-like lymphoma which is associated with a facilitated induction of FoxP3+ Treg cells. Our results suggest that through regulating the induction of Treg cells, golli protein affect the progression of Hodgkin’s-like lymphoma. |
| Databáze: | OpenAIRE |
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