Synthesis, Antimicrobial, and Antioxidant Studies of Some New Indolo[3,2-c]isoquinoline Derivatives
| Autor: | Vaijinath A. Verma |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Antioxidant
biology 010405 organic chemistry Chemistry medicine.medical_treatment General Chemistry 010402 general chemistry biology.organism_classification Antimicrobial 01 natural sciences Combinatorial chemistry 0104 chemical sciences Ferrous chemistry.chemical_compound medicine Chelation Isoquinoline Bacteria |
| Zdroj: | Russian Journal of General Chemistry. 88:2628-2645 |
| ISSN: | 1608-3350 1070-3632 |
| DOI: | 10.1134/s1070363218120265 |
| Popis: | As a part of systematic study, new series of 6-{[5-(5-substituted 2-phenyl-1H-indol-3-yl)- methyleneamino]-1,3,4-oxadiazol-2-yl}-8-substituted-6H-indolo[3,2-c]isoquinolin-5(11H)-ones and their derivatives are synthesized and evaluated for their biological activities. Compound 8a displays potent antimicrobial activity against bacteria E. coli, K. penumoniae, and S. aureus, and fungi A. niger, A. flavus, and A. fumigates. Compounds 7a and 8a demonstrate promising radical scavenging and chelating with ferrous ions (Fe2+). According to the accumulated data the designed motifs exhibit higher biological activities than the reference compounds. |
| Databáze: | OpenAIRE |
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