Effects of Selective M1 Muscarinic Receptor Activation on Hippocampal Spatial Representations and Neuronal Oscillations
| Autor: | Allan I. Levey, Chun Hu, John B. Trimper, Joseph R. Manns, Evan P. Lebois |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Allosteric modulator Physiology medicine.drug_class Cognitive Neuroscience Place cell Hippocampus Cell Biology General Medicine Hippocampal formation Biochemistry 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Acetylcholinesterase inhibitor Muscarinic acetylcholine receptor Muscarinic acetylcholine receptor M4 medicine Donepezil Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | ACS Chemical Neuroscience. 7:1393-1405 |
| ISSN: | 1948-7193 |
| DOI: | 10.1021/acschemneuro.6b00160 |
| Popis: | The muscarinic M1 acetylcholine receptor is a key target for drugs aimed at treating cognitive dysfunction, including the memory impairment in Alzheimer’s disease. The overall question of the current study was to ask how systemic administration of the bitopic M1 agonist VU0364572, the M1 positive allosteric modulator BQCA, and the acetylcholinesterase inhibitor donepezil (current standard of care for Alzheimer’s disease), would impact spatial memory-related hippocampal function in rats. Hippocampal pyramidal neuron spiking and local field potentials were recorded from regions CA1 and CA3 as rats freely foraged in a recording enclosure. To assess the relative stability versus flexibility of the rats’ spatial representations, the walls of the recording enclosure were reshaped in 15-m intervals. As compared to the control condition, systemic administration of VU0364572 increased spatial correlations of CA1 and CA3 pyramidal neuron spiking across all enclosure shape comparisons, whereas BQCA and donepezil app... |
| Databáze: | OpenAIRE |
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