Real-world treatment patterns and clinical outcomes of HCV treatment-naive patients in China: an interim analysis from the CCgenos study
| Autor: | Hong Chen, Jun Li, Guozhong Gong, Jianning Jiang, Zuojiong Gong, Hong Li, Jia Shang, Lei Wang, Qing Xie, Wei-Bo Yang, Lai Wei, Yongtao Sun, Junqi Niu, Hui Ying Rao, Ruifeng Yang, Zhi Liang Gao, Longfeng Zhao, Mei Hsuan Lee, Lunli Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Hepatology business.industry Gastroenterology Interim analysis medicine.disease Unmet needs Therapy naive 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Virologic response Internal medicine Clinical information Cohort Immunology Hcv treatment Medicine 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 32:244-252 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.13467 |
| Popis: | Background and AimIn China, chronic hepatitis C virus (HCV) infection represents a considerable healthcare burden. Although interferon-based therapy has been the standard-of-care for many years, few long-term, real-life studies have assessed interferon-based treatment in China. The objective of CCgenos follow-up study was to analyze long-term treatment patterns and outcomes in a cohort of treatment-naive, Han ethnic, patients with chronic HCV infection. MethodsPatients who had participated in the CCgenos cross-sectional study were invited to enter this 5-year follow up. Clinical information and centralized HCV-RNA measures were collected at scheduled study visits every 6months for untreated patients and every 3months for treated patients. ResultsAmong 512 patients enrolled, 334 (65.2%) received interferon-based treatment and 178 (34.8%) remained untreated over a median of 4.1 (1.2-4.3) years. A total of 82.8% (424/512) of patients had an IL28B CC genotype (GT); 60.7% (311/512) had HCV GT1b infection, including 121 (38.9%) untreated. Most patients with baseline cirrhosis were untreated (26/46, 56.5%). Among patients who completed treatment and 24weeks of post-treatment follow up, the duration of interferon-based therapy was frequently longer than recommended (52.9% [92/174] of GT1b-infected were treated for >1year). Rates of sustained virologic response (SVR24) were 71.1% (226/318) overall; 62.4% (111/178) among patients with HCV GT1b infection; and 42.9% (15/35) among patients with cirrhosis. ConclusionsThere remains a high unmet need for effective HCV treatment in China, evidenced by a high proportion of patients remaining untreated by the current standard-of-care and relatively low SVR24 rates for patients with both GT1b infection and cirrhosis. |
| Databáze: | OpenAIRE |
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