Technique Paper for Wet-Spinning Poly(L-lactic acid) and Poly(DL-lactide-co-glycolide) Monofilament Fibers
| Autor: | Andres A. Romero, George M. Smith, Brent B. Crow, Kevin D. Nelson, Angela Borneman, Paula Waggoner |
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| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Tissue Engineering. 9:1323-1330 |
| ISSN: | 1557-8690 1076-3279 |
| DOI: | 10.1089/10763270360728233 |
| Popis: | A simple and repeatable method is described for wet-spinning poly(L-lactic acid) (PLLA) and poly(DL-lactic-co-glycolic acid) (PLGA) monofilament fibers. These fibers are strong, elastic, and suitable for many applications, including use as tissue-engineering scaffolds. The PLLA wet-extruded fibers do not show additional strain-induced crystallization as a result of drawing the fibers during fabrication; however, there is an apparent increase in crystallinity late in the degradation process in saline at 37 degrees C. We have measured the molecular weight degradation in saline at 37 degrees C for fibers of both PLLA and PLGA. Changing solvent systems, polymer blends, and winding rates alters mechanical and morphological properties of these fibers for specific applications. The authors discuss a possible theoretical explanation for these observed changes due to changes in polymer concentration, solvent system, and coagulation bath properties. This wet-extrusion process is simple and inexpensive enough to be carried out in almost any laboratory interested in tissue engineering. |
| Databáze: | OpenAIRE |
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