Synthesis and biological activity of arylaliphatic N-(2-aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides

Autor:	E. Yu. Afanas’eva, E. Ya. Borisova, N. Yu. Borisova, O. S. Kaldyrkaeva, E. V. Arzamastsev, D. Q. Hoang, N. Yu. Asilova, E. L. Levitskaya, O. A. Terekhova
Rok vydání:	2018
Předmět:	chemistry.chemical_compound chemistry Low toxicity 010405 organic chemistry Styrene oxide Ethylenediamines Biological activity General Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences Medicinal chemistry 0104 chemical sciences
Zdroj:	Russian Chemical Bulletin. 67:131-136
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-018-2048-0
Popis:	N-(2-Aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides were synthesized from styrene oxide by ring opening with N,N-disubstituted ethylenediamines followed by N-acylation. Synthesized compounds have pronounced antiarrhythmic activity and low toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::da18a885ae28bc40d2a66c1ef1e4fbf0 https://doi.org/10.1007/s11172-018-2048-0 Zobrazit plný text záznamu Full text from SpringerLink