Chitosan-based scaffolds in orthopedic applications
| Autor: | K. Tuzlakoglu, R.L. Reis |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_classification
Materials science Biocompatibility Cartilage macromolecular substances 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Chitosan chemistry.chemical_compound medicine.anatomical_structure chemistry Tissue engineering Biological property medicine 0210 nano-technology Biomedical engineering |
| DOI: | 10.1533/9781845694814.3.357 |
| Popis: | Publisher Summary The term, “Chitosan” refers to a family of de-N-acetylated chitins with different degrees of deacetylation. Depending on the degree of deacetylation and on the N-acetlyglucosamine group distribution along the polymer chains, it can completely degrade into small glycomino chains in vivo. Currently, chitosan seems to be one of the most promising polymers for successful repair of bone and cartilage due to its several distinctive biological properties including good biocompatibility, biodegradability, and wound healing effect. Moreover, it can easily be formed into 3D porous structures which act as scaffolds in tissue engineering applications. However, there are still some drawbacks to be overcome such as insufficient mechanical properties and long degradation period. Combination of chitosan-based scaffolds with different polymers and ceramics and the use of new cell sources and growth factors would hopefully improve the success of chitosan in tissue engineering of bone and cartilage and allow its use in orthopedic clinical applications. |
| Databáze: | OpenAIRE |
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