Intramolecular cycloadditions with azomethine ylides for the synthesis of metacyclophanes
| Autor: | P. von Laer, Hans Fritz, I. Heinze, P. Link, Wolfgang Eberbach |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
chemistry.chemical_classification
Intramolecular reaction Organic Chemistry Azomethine ylide Nuclear magnetic resonance spectroscopy Thermal treatment Photochemistry Biochemistry Medicinal chemistry Cycloaddition chemistry.chemical_compound chemistry Intramolecular force Drug Discovery Lactone Cyclophane |
| Zdroj: | Tetrahedron Letters. 27:4003-4006 |
| ISSN: | 0040-4039 |
| Popis: | On thermal treatment of the aziridines 5a - f intramolecular cycloaddition reactions of the intermediate azomethine ylides 6 result in the formation of the metacyclophanes 7 - 9 . For 7a and 7b the conformational barriers areestimated to be approximately 20 and 12 kcal/mol, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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