COX-2 Polymorphisms in Patients With Familial Adenomatous Polyposis

A and -765G-->C) in COX-2. Logistic regression analysis revealed an overrepresentation of the -1195GG genotype compared to the -1195AA genotype in patients with FAP (odds ratio = 2.81; 95% CI = 1.00-7.91, p = 0.042). No associations between single COX-2 polymorphisms or COX-2 haplotype were found when patients were evaluated according to their Spigelman stage. The predicted low COX-2 expression genotype -1195GG was found overrepresented in the patients with FAP. The COX-2 genotypes showed no association with the severity of duodenal adenomatosis. -->
ISSN: 0965-0407
DOI: 10.3727/096504009788428451
Přístupová URL adresa: https://explore.openaire.eu/search/publication?articleId=doi_________::d9fa896a392e3a01d8b71145735dd562
https://doi.org/10.3727/096504009788428451
Přírůstkové číslo: edsair.doi...........d9fa896a392e3a01d8b71145735dd562
Autor: Hennie M.J. Roelofs, Fokko M. Nagengast, Elisabeth M. H. Mathus-Vliegen, Marloes Berkhout, Wilbert H.M. Peters, Rene H. M. te Morsche
Rok vydání: 2009
Předmět:
Zdroj: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 17:347-351
ISSN: 0965-0407
DOI: 10.3727/096504009788428451
Popis: Cyclooxygenase-2 (COX-2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes such as inflammation, cell proliferation, and angiogenesis. COX-2 has been found overexpressed in (pre)malignant tissues and may be relevant to cancer development. We investigated whether functional genetic polymorphisms in COX-2 may have a risk-modifying effect on duodenal adenomatosis in patients with familial adenomatous polyposis (FAP). Blood from 85 patients with FAP and 218 age- and sex-matched healthy subjects was investigated for the presence of two functional promoter region polymorphisms (-1195G-->A and -765G-->C) in COX-2. Logistic regression analysis revealed an overrepresentation of the -1195GG genotype compared to the -1195AA genotype in patients with FAP (odds ratio = 2.81; 95% CI = 1.00-7.91, p = 0.042). No associations between single COX-2 polymorphisms or COX-2 haplotype were found when patients were evaluated according to their Spigelman stage. The predicted low COX-2 expression genotype -1195GG was found overrepresented in the patients with FAP. The COX-2 genotypes showed no association with the severity of duodenal adenomatosis.
Databáze: OpenAIRE
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