The impact of diabetes mellitus on carotid atherosclerosis and arterial stiffness; results from the Corinthia study
| Autor: | M Anastasiou, Petros Fountoulakis, Georgios Lazaros, Georgia Vavouranaki, Athina Goliopoulou, Margenti Papakonstantinou, E Oikonomou, Dimitrios Tousoulis, Sotiris Tsalamandris, Panagiotis Theofilis, Gerasimos Siasos, Christos Chasikidis, Georgia Vogiatzi, Evangelia Christoforatou, Vasiliki-Xara Mystakidi |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | European Heart Journal. 42 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehab724.2620 |
| Popis: | Background Evaluation of arterial stiffness and carotid atherosclerotic burden can provide important prognostic information regarding the risk for future cardiovascular events. In that context, we tried to determine those vascular properties of diabetic individuals compared to non-diabetics. Methods In this analysis of the observational “Corinthia” study, we included 1757 participants with determined diabetic status. Propensity scores were employed to match diabetics to non-diabetics with regards to known cardiovascular risk factors. Carotid ultrasonography was performed to evaluate intima-media thickness (cIMT) across the common carotid arteries and the carotid bulbs as well as carotid plaque burden. Arterial stiffness was estimated via assessment of carotid-to-femoral pulse wave velocity (cfPWV). Results Diabetic individuals had increased mean cIMT (diabetics: 1.12±0.50mm vs. 0.94±0.38mm, p Conclusion We observed increased carotid artery intima-media thickness and cfPWV in individuals with diabetes mellitus. As opposed to non-diabetics, carotid lesions in diabetics were more pronounced in the carotid bulb and not in the common carotid artery. Our findings may raise awareness regarding the focus of atherosclerotic echocardiographic examination in subjects with diabetes mellitus while the impact of glucose-lowering therapies on these specific vascular lesions merits further assessment. Funding Acknowledgement Type of funding sources: None. Figure 1Figure 2 |
| Databáze: | OpenAIRE |
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