Biphasic nucleophilic aromatic substitution using a microreactor under droplet formation conditions
| Autor: | Toshiaki Hanasaka, Yasuhiro Nishiyama, Hajime Mori, Hideyuki Koishi, Hitoshi Torikai, Akira Fujii, Akane Saito |
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| Rok vydání: | 2021 |
| Předmět: |
Fluid Flow and Transfer Processes
chemistry.chemical_classification Ketone Chemistry Process Chemistry and Technology education Photochemistry humanities Catalysis Chemistry (miscellaneous) Nucleophilic aromatic substitution Phase (matter) Scientific method Chemical Engineering (miscellaneous) Microreactor Solvent effects |
| Zdroj: | Reaction Chemistry & Engineering. 6:720-725 |
| ISSN: | 2058-9883 |
| DOI: | 10.1039/d1re00014d |
| Popis: | The biphasic nucleophilic aromatic substitution of 4-fluoronitrobenzene was carried out using a microreactor. To realize an efficient reaction process, we performed microflow reactions under droplet formation conditions to give the substituted products in excellent yields. The solvent effect was also investigated, and it was found that the use of diisobutyl ketone as an organic phase greatly accelerated the reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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