The increased tumour-inhibitory effect of enzyme-activated nitrogen mustards

Autor:	P. Hebborn, J.F. Danielli
Rok vydání:	1958
Předmět:	Pharmacology chemistry.chemical_classification Stereochemistry chemistry.chemical_element Biochemistry Nitrogen Acylation chemistry.chemical_compound Enzyme chemistry Biological property Toxicity lipids (amino acids peptides and proteins) Selectivity Inhibitory effect Acyl group
Zdroj:	Biochemical Pharmacology. 1:19-24
ISSN:	0006-2952
DOI:	10.1016/0006-2952(58)90004-2
Popis:	Studies have been made of the effect of acylation on various biological properties of the compounds NH 2 N(CH 2 CH 2 Cl) 2 and HO N(CH 2 CH 2 Cl) 2 . Acylation decreases the toxicity of the compounds to rats. The selective toxicity of the acylated derivatives for Walker sarcoma 256 may be strikingly higher or lower than that of the parent compounds. When the tumour contains an enzyme capable of splitting off the acyl group, selectivity is increased. When the tumour does not contain an appropriate enzyme, the selectivity is decreased.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d9cf1af583a8d7deb10d98e14f34b7f1 https://doi.org/10.1016/0006-2952(58)90004-2 Zobrazit plný text záznamu