Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content
| Autor: | Yasuhiro Shibata, Takahiro Shuto, Yoshitaka Sekine, Hiroshi Matsui, Hidekazu Koike, Seiji Arai, Kazuto Ito, Masashi Nomura, Kazuhiro Suzuki, Yoshiyuki Miyazawa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class Urology Biology Androgen Dutasteride Steroidal antiandrogen 03 medical and health sciences 5 Alpha-Reductase Inhibitor Chlormadinone acetate chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology medicine.anatomical_structure Oncology chemistry Prostate 030220 oncology & carcinogenesis Dihydrotestosterone Internal medicine medicine Hormone metabolism medicine.drug |
| Zdroj: | The Prostate. 77:672-680 |
| ISSN: | 0270-4137 |
| DOI: | 10.1002/pros.23315 |
| Popis: | BACKGROUND The effects of a steroidal antiandrogen (AA) and 5-alpha-reductase inhibitor (5ARI) on prostate tissue hormone content and metabolism are not fully elucidated. The objective of this study is to investigate the hormone content and metabolism of the prostate tissues of patients treated with AA or 5ARI using the ultra-sensitive liquid chromatography–tandem mass spectrometry (LC-MS/MS) method. METHODS Thirty-nine patients with benign prostatic hyperplasia (BPH) undergoing transurethral surgery were included. Serum and prostate tissue hormone and prostate tissue hormone metabolism analyses were performed using LC-MS/MS after 1 month of treatment with chlormadinone acetate (CMA; steroidal AA, 50 mg/day) or dutasteride (DUTA; dual 5ARI, 0.5 mg/day). RESULTS Serum testosterone (T), dihydrotestosterone (DHT), and adrenal androgen levels were lower in the CMA group than the control group. Prostate tissue T and DHT levels were also lower in the CMA group than the control group. In the DUTA group, only serum and prostate DHT concentrations were reduced compared to the control group; in contrast, those of other hormones, especially T and 4-androstene-3,17-dione in the prostate tissue, showed marked elevations up to 70.4- and 11.4-fold normal levels, respectively. Moreover, the hormone metabolism assay confirmed that the conversion of T to DHT was significantly suppressed while that of T to 4-androstene-3,17-dione was significantly accelerated in the prostate tissue of DUTA-treated patients. CONCLUSIONS Although treatment with AA and 5ARI show similar clinical outcomes, their effect on tissue hormone content and metabolism varied greatly. Prostate 9999: XX–XX, 2017. © 2017 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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