Effects of Time Delay on Multistability of Genetic Toggle Switch

Autor:	Huijun Jiang, Zhonghuai Hou, De-qing Zhu
Rok vydání:	2015
Předmět:	Physics Low protein Plane (geometry) State (functional analysis) Physical and Theoretical Chemistry Toggle switch Topology Multistability Phase diagram Delay time
Zdroj:	Chinese Journal of Chemical Physics. 28:727-732
ISSN:	2327-2244 1674-0068
DOI:	10.1063/1674-0068/28/cjcp1505113
Popis:	The effect of time delay on a genetic toggle switch, whose undelayed dynamics shows low protein expression states (L-states), high expression states (H-states) and coexistence of them different transcription-factor binding rates α, is investigated by using the delayed stochastic simulation method. Interestingly, we find that the delay induces a transition from the coexistence state to L-state or H-state by suppressing the other state. Moreover, the phase diagram on the α-τ plane is obtained by extensive simulations. It is observed that, the coexistence state is remarkably narrowed by increasing delay time, and completely disappears above a triple-point-like point where direct transitions between H-state and L-state are possible.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d9c74f120e2330f6a7ad830cc64278ae https://doi.org/10.1063/1674-0068/28/cjcp1505113 Zobrazit plný text záznamu