Fetal cardiac implications of maternal systemic diseases
| Autor: | Edilberto Martinez, Ann Tan Sian, Charles S. Kleinman, Joshua A. Copel |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty Fetus business.industry Offspring Transmission (medicine) Physiology Connective tissue medicine.disease Connective tissue disease Pathogenesis medicine.anatomical_structure Diabetes mellitus Pediatrics Perinatology and Child Health Etiology Medicine Cardiology and Cardiovascular Medicine business |
| Zdroj: | Progress in Pediatric Cardiology. 5:91-101 |
| ISSN: | 1058-9813 |
| DOI: | 10.1016/1058-9813(95)00154-9 |
| Popis: | Maternal systemic diseases may have an impact on the development of the fetus. Teratogenic risks are increased by some of these diseases, for example, diabetes mellitus and phenylketonuria. Malformations of the fetal heart may result from toxic insults during post-conceptional weeks 3 to 8 (critical period of embryogenesis). Diabetes mellitus remains a major contributor to perinatal morbidity secondary to macrosomia and fetal congenital anomalies. Structural as well as functional fetal cardiac anomalies are among the most commmon abnormalities reported. Phenylketonuria is an inborn error of pheynlalanine metabolism which has an autosomal recessive transmission. An increased incidence of cardiac anomalies have been reported in the offspring of affected individuals if dietary treatment is relaxed during organogenesis. Connective tissue diseases are a diverse group of multisystem disorders some of which are autoimmune in etiology. Maternal connective tissue disease may lead to neonatal lupus syndrome which may include transient cutaneous lesions, congenital complete heart block, or both. We discuss the pathogenesis, prevention, management, and consequences of the most common maternal systemic diseases with fetal cardiac implications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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