A convenient synthesis of new biological active 5-imino-4-thioxo-2-imidazolidinones involving acetonitrile electrogenerated base

Autor:	Beya Haouas, Najwa Sbei, Mohamed Lamine Benkhoud, Fructuoso Barba, Belen Batanero, L. Fuentes
Rok vydání:	2015
Předmět:	Carbon disulfide Magnesium Galvanic anode Cyanide Organic Chemistry chemistry.chemical_element Biochemistry Decomposition Combinatorial chemistry chemistry.chemical_compound chemistry Drug Discovery Graphite Acetonitrile Derivative (chemistry)
Zdroj:	Tetrahedron. 71:7654-7657
ISSN:	0040-4020
DOI:	10.1016/j.tet.2015.07.066
Popis:	3-Benzyl-5-imino-4-thioxo-2-imidazolidinones are obtained in good yields by using commercially available starting compounds when, under low temperature conditions, a solution of dry acetonitrile is electrolyzed at a graphite sheet as cathode to produce cyanomethyl anion as EGB, that is further reacted with benzylamines, CS 2 and isocyanates. The use of a magnesium rod, as sacrificial anode, is definitive to avoid 3-aminocrotonitrile anion formation. Mechanism proposal is given where cyanide is formed ‘in situ’ by decomposition of the first electrogenerated organomagnesium derivative.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d9aa5bb47c88695ba41f93c9fe6aa714 https://doi.org/10.1016/j.tet.2015.07.066 Zobrazit plný text záznamu Full Text from ScienceDirect