Metabolism of bromobenzene

Autor:	K. Lertratanangkoon, Marjorie G. Horning, Evan C. Horning
Rok vydání:	1987
Předmět:	Stereochemistry Metabolite Organic Chemistry Aromatization chemistry.chemical_element General Medicine Metabolism Glutathione Biochemistry Sulfur Analytical Chemistry chemistry.chemical_compound chemistry Bromobenzene Rat liver
Zdroj:	Journal of Chromatography A. 399:321-339
ISSN:	0021-9673
DOI:	10.1016/s0021-9673(00)96134-x
Popis:	Our studies of bromobenzene metabolism have shown that the 3,4-oxide is metabolized to 3- and 4-bromophenol through an extended glutathione pathway. The mechanism of sulfur elimination from a dihydrobromobenzene metabolite is not known, although it is known that the aromatization reaction will occur in a 9000- g supernatant fraction of rat liver. The hepatotoxic and nephrotoxic metabolites of bromobenzene are most likely bromothiocatechols and a bromothiopyrogallol, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d9aa21426412e0dc3e7ba3b3ee99788c https://doi.org/10.1016/s0021-9673(00)96134-x Zobrazit plný text záznamu