Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function

Autor:	Divya Narayanan, Paul G. Arrigg, Mark B. Abelson, Rajkumar Patil, John David Rodriguez, Garrick Wallstrom, Matthew Jonathan Chapin, Donna Welch
Rok vydání:	2020
Předmět:	medicine.medical_specialty genetic structures media_common.quotation_subject Magnification Drusen Pigment changes 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine Contrast (vision) media_common business.industry Significant difference Retinal Macular degeneration medicine.disease eye diseases chemistry Visual function 030221 ophthalmology & optometry sense organs business 030217 neurology & neurosurgery
Zdroj:	Clinical Ophthalmology. 14:2571-2576
ISSN:	1177-5483
DOI:	10.2147/opth.s260787
Popis:	Purpose Early detection and treatment of age-related macular degeneration require a clear understanding of the early progress of the disease. The purpose of this study was to investigate whether minimal macular ophthalmoscopic changes corresponded to changes in visual function. Methods Color macular photos from a group of older subjects who were classified as grade 0 on AREDS simplified grading were further evaluated by a retinal specialist using 5x magnification for possible minimal macular anomalies. Group 0-A (N = 15) were defined as subjects with no visible macular anomalies while Group 0-B (N = 19) comprised subjects for whom minimal macular mottling, pigment changes or very small drusen (< 63 µm) were observed in the study eye. All subjects had best VA of 20/25 or better and had no evidence of other retinal diseases in the study eye. All subjects underwent a series of visual function tests such as standard ETDRS VA, low luminance ETDRS VA, Pelli-Robson contrast sensitivity, variable contrast flicker (VCF) sensitivity, and reading speed (words per minute, wpm) using both MNRead and low luminance reading on a tablet. Results There was no significant difference between the mean age between the two groups (74.8 ± 5.2 years for 0-A vs 74.5 ± 4.4 for 0-B, p = 0.82). None of the visual function tests identified any significant difference between the two groups. Mean ETDRS VA was 0.0 ± 0.11 for 0-A subjects and 0.08 ± 0.12 for 0-B (p = 0.063). Mean Pelli-Robson log contrast sensitivity was 1.75 ± 0.29 for 0-A and 1.78 ± 0.17 for the 0-B group (p = 0.73). VCF threshold was 0.47 ± 0.25 for 0-A and 0.43 ± 0.22 for 0-B (p = 0.64). Reading speed using MNRead was 214 ± 47.4 wpm for 0-A and 210 ± 64.7 for 0-B (p = 0.85). Low luminance tablet reading speed was 137 ± 71.8 wpm for 0-A and 151 ± 39.4 (0-B) (p = 0.49). Conclusion A panel of psychophysical tests did not demonstrate significant differences between subjects with and without minimal macular changes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d9955d76b10eb02c63b4ab15bb057666 https://doi.org/10.2147/opth.s260787 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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