Transfusion-related acute lung injury after intravenous immunoglobulin treatment in a lung transplant recipient
| Autor: | P. Camus, Olivier Brugière, Gabriel Thabut, F. Delbos, A.-C. Metivier, Gaëlle Dauriat, Hervé Mal, A. Stoclin, N. Boeri |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
biology business.industry medicine.medical_treatment Hematology General Medicine Lung injury medicine.disease Surgery Transplantation hemic and lymphatic diseases Anesthesia Pulmonary fibrosis medicine biology.protein Lung transplantation Lung transplant recipient Antibody business IVIG Therapy Transfusion-related acute lung injury |
| Zdroj: | Vox Sanguinis. 104:175-178 |
| ISSN: | 0042-9007 |
| DOI: | 10.1111/j.1423-0410.2012.01645.x |
| Popis: | Three weeks after single-lung transplantation for pulmonary fibrosis, a patient with high serum levels of de novo donor-specific antibodies received high-dose intravenous immunoglobulin (IVIG) infusion (scheduled dose: 2 g/kg on 2 days) to prevent antibody-mediated rejection. Within the first hours after completion of infusions, he experienced acute lung injury involving the transplanted lung. Given the clinical evolution and the absence of an alternative diagnosis, transfusion-related acute lung injury (TRALI) was diagnosed. The IVIG administered on each day was from the same batch. At day 110, because of an increase in the serum titers of donor-specific antibodies, IVIG therapy was reintroduced but from a different batch, with excellent clinical tolerance. The lung injury was explored biologically, but no mechanism was revealed. Given the increasing use of IVIG in solid-organ recipients, clinicians should be aware of possible TRALI after IVIG infusion. |
| Databáze: | OpenAIRE |
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