Requirements for human iPS cell-derived hepatocytes as an alternative to primary human hepatocytes for assessing absorption, distribution, metabolism, excretion and toxicity of pharmaceuticals

Autor:	Tomoaki Inoue, Masato Ohbuchi, Makiko Motoi, Naoki Ishiguro, Atsushi Sakamoto, Keisuke Nagata, Sakae Sakamoto, Yumiko Iwase, Masahiro Uto, Ryota Ise, Hiroyuki Moriguchi, Yasuharu Nakanishi, Tetsuro Araki, Raku Shinkyo, Toshiki Homma, Norihiko Iwazaki
Rok vydání:	2016
Předmět:	0301 basic medicine biology Cytochrome P450 Absorption (skin) Metabolism Pharmacology Excretion 03 medical and health sciences 030104 developmental biology Biochemistry Toxicity biology.protein Distribution (pharmacology) Induced pluripotent stem cell Drug metabolism
Zdroj:	Fundamental Toxicological Sciences. 3:89-99
ISSN:	2189-115X
DOI:	10.2131/fts.3.89
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d99275f789166738e3390283ac11f2c8 https://doi.org/10.2131/fts.3.89 Zobrazit plný text záznamu