Mechanism of Action of an Anti-Candida Drug: Amphotericin B and Its Derivatives
| Autor: | J. Bolard |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Drug
chemistry.chemical_classification Ergosterol media_common.quotation_subject Antifungal drug Biology Pharmacology Polyene biology.organism_classification chemistry.chemical_compound Mechanism of action chemistry Amphotericin B medicine Azole medicine.symptom Candida albicans media_common medicine.drug |
| Zdroj: | Candida Albicans ISBN: 9783642752551 |
| Popis: | The selection of anti-Candida drugs is based on their selective toxicity towards the fungal pathogen. The toxicity in turn depends on the cellular constituents and their biosynthetic pathways in the pathogen. Fungi, like host cells, are also eukaryotic organisms and hence both are similar in most respects. The presence of ergosterol in the fungal membranes instead of cholesterol in the host membranes has been the basis of the development of the two principal categories of antifungal drugs: polyene antibiotics and azole derivatives. Many chemotherapists have so far unsuccessfully directed their efforts in targeting new drugs to Candida’s cell wall. The approach in any case offers great promise. The most recent and important developments have been in the field of azole derivatives, the polyene antibiotics and their delivery by liposomes, and the drugs aimed against the fungal cell wall. With regard to other antifungal drugs and their mechanism of action, no significant progress has been made. Several books have been entirely devoted to antifungal chemotherapy [39,146,158]. There are also excellent articles published on all the antifungal drugs [44,104,75,160] or more specifically, the polyene antibiotics [12,41,77,103,132] and the azole derivatives [159]. The phenotypic resistance of Candida albicans to polyene antibiotics has also been reviewed [42,134]. This chapter is mainly devoted to updating our knowledge and to the proposal of new interpretations of the mechanism of action of the polyene, amphotericin B (AmB) and its derivatives. |
| Databáze: | OpenAIRE |
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