| Popis: |
This review concentrates on prodrugs designed by pharmaceutical chemists to overcome biopharmaceutical or pharmacokinetic (essentially metabolic) problems encountered with active principles. The investigations presented in this review illustrate the types of problems pharmaceutical chemists have tried to solve and the metabolic, kinetic, or biopharmaceutical rationale behind these attempts. Although very little published information is available on pharmacokinetic methods useful in the study of prodrugs and on the regulatory requirements needed for prodrug development, the authors have tried to develop some general ideas that might be useful in this regard. Keywords: prodrug design; chemical bond; gastrointestinal absorption; parenteral administration; drug distribution; transdermal absorption; ocular absorption |
