Combining Raman spectroscopy and optical coherence tomography for correlated interpretation of morpho-molecular features on early stage bladder cancer
| Autor: | Gregers Gautier Hermann, Wolfgang Drexler, Iwan W. Schie, Jürgen Popp, Simon Kretschmer, Thomas Hasselager, Eliana Cordero Bautista, Fabian Placzek, Lara M. Wurster, Caglar Ataman, Hans Zappe, Florian Knorr, Karin Mogensen, Rainer A. Leitgeb |
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| Rok vydání: | 2021 |
| Předmět: |
Multimodal imaging
Bladder cancer genetic structures biology medicine.diagnostic_test business.industry Morpho biology.organism_classification medicine.disease Stage bladder cancer eye diseases Imaging modalities symbols.namesake Nuclear magnetic resonance Optical coherence tomography symbols Medicine sense organs business Raman spectroscopy |
| Zdroj: | Multimodal Biomedical Imaging XVI. |
| DOI: | 10.1117/12.2579561 |
| Popis: | Using the multimodal combination of optical coherence tomography (OCT) with Raman spectroscopy (RS) for obtaining morpho-molecular tissue characteristics of suspicious bladder cancer lesions for improved diagnostics and signal origin characterization. We present endoscopically acquired co-localized OCT-RS data on bladder cancer biopsies. The correlated OCT and RS data enables a new way of interpretation and understanding of signal origin for both imaging modalities. Histopathological findings serve as ground truth. Molecular signal contributions can be directly correlated to identified morphological features from the OCT and lead to a better understanding of underlying biological structures. |
| Databáze: | OpenAIRE |
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