Modulation of the Acetylcholine-Induced Input Current by Noopept in Helix Lucorum Neurons
| Autor: | G. B. Murzina, Arkady S. Pivovarov |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
030102 biochemistry & molecular biology biology Chemistry Biophysics Helix lucorum biology.organism_classification 03 medical and health sciences 030104 developmental biology Nicotinic agonist Modulation Muscarinic acetylcholine receptor medicine Current (fluid) Acetylcholine Acetylcholine receptor Noopept medicine.drug |
| Zdroj: | Biophysics. 64:393-399 |
| ISSN: | 1555-6654 0006-3509 |
| DOI: | 10.1134/s0006350919030151 |
| Popis: | —Possible causes of the positive modulating effect of noopept (in a concentration range of 0.1 to 10 nM) on the amplitude of the acetylcholine-induced input current are analyzed using a developed mathematical model. The results revealed that the calculated and experimental current curves coincide when the number of nicotinic acetylcholine receptors on the neuron membrane is increased or the efficiency of muscarinic acetylcholine receptors is changed. |
| Databáze: | OpenAIRE |
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