Low Reactivity of Peripheral Blood Dendritic Cells Respond to IL-1 and GM-CSF in SLE Patients

Autor:	Toshihisa Fujimaki, Yuji Akiyama, Fumihiko Imai, Teruhiko Suzuki, Toshiko Ishibashi
Rok vydání:	1995
Předmět:	biology business.industry T cell Case-control study Interleukin Peripheral blood Granulocyte macrophage colony-stimulating factor medicine.anatomical_structure Concanavalin A Immunology medicine biology.protein In patient business Antigen-presenting cell medicine.drug
Zdroj:	Advances in Experimental Medicine and Biology ISBN: 9781461358114
Popis:	We reported previously that peripheral blood dendritic cells (PBDCs) have strong accessory cell (AC) function and are more potent ACs than macrophages. Further, IL-1 and GM-CSF were found to act on PBDCs but not on T cells, as a result, they enhance the concanavalin A (Con A)-stimulated T cell proliferative response1. Also, the Con A- stimulated Tcell proliferation was reduced significantly in SLE patients compared to normal subjects2. Therefore, we investigated whether the PBDC function in patients with SLE can be restored by IL-1 and GM-CSF.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d96bb3ca99e6177ec13965567dab67ee https://doi.org/10.1007/978-1-4615-1971-3_86 Zobrazit plný text záznamu