Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties
| Autor: | Marek Nečas, Michaela Fojtu, Jindriska Leischner Fialova, Martin Sojka, Michal Masarik, Radek Marek |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Rotaxane
010405 organic chemistry Supramolecular chemistry Cationic polymerization chemistry.chemical_element Biological activity 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Ruthenium Inorganic Chemistry Hydrolysis chemistry Cucurbituril Biological property Physical and Theoretical Chemistry |
| Zdroj: | Inorganic Chemistry. 58:10861-10870 |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/acs.inorgchem.9b01203 |
| Popis: | We report here the first coupling of Ru(II) units with cucurbit[6/7]uril-based pseudorotaxane ligands meant for biological application. The resulting ruthenium-capped rotaxanes were fully characterized, and a structure of one supramolecular system was determined by X-ray diffraction. Because the biological properties of Ru-based metallodrugs are tightly linked to the ligand-exchange processes, the effect of salt concentration on the hydrolysis of chlorides from the Ru(II) center was monitored by using 1H NMR spectroscopy. The biological activity of Ru(II)-based rotaxanes was evaluated for three selected mammalian breast cell lines, HBL-100, MCF-7, and MDA-MB-231. The antimetastatic activity of the assembled cationic Ru(II)-rotaxane systems, evaluated in migration assays against MCF-7 and MDA-MB-231 cell lines, is notably enhanced compared to that of RAPTA-C, a reference that was used. The indicated synergistic effect of combining Ru(II) with a pseudorotaxane unit opens a new direction in searching for anticancer supramolecular metallodrugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|