Role of oxygen in wound healing: a review of evidence

Autor:	D J Leaper, A C Chambers
Rok vydání:	2011
Předmět:	medicine.medical_specialty Nursing (miscellaneous) business.industry Angiogenesis Bacterial killing Surgery Search terms Medicine Fundamentals and skills Animal studies Cutaneous wound business Intensive care medicine Methodological quality Wound healing Surgical site infection
Zdroj:	Journal of Wound Care. 20:160-164
ISSN:	2052-2916 0969-0700
DOI:	10.12968/jowc.2011.20.4.160
Popis:	objective: To review the evidence regarding the infuence of oxygen as an intrinsic factor on cutaneous wound healing. Method: A literature search was performed using Ovid and the Cochrane Database with the search terms: ‘Wound healing’, ‘Oxygen’, ‘Collagen’, ‘Angiogenesis’, ‘Infammation’ and ‘Surgical Site Infection’. Human and animal studies were included if relevant and examined for methodological quality. results: There are no meta-analyses of the use of oxygen in wound healing and only two randomised controlled trials (RCTs). Studies vary in methodological quality. The majority of the data comes from animal models. In total 1568 studies on wound healing and oxygen were found. conclusion: Oxygen is vital throughout wound healing, especially in the infammatory and proliferative phases. Research suggests that patient supplementation with oxygen could enhance bacterial killing and angiogenesis, reduce surgical site infection rates and increase wound tensile strength, facilitating improved healing. confict of interest: None.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d968eb32d61e276ef14b0eaff7b924b1 https://doi.org/10.12968/jowc.2011.20.4.160 Zobrazit plný text záznamu