Aza-Michael reaction as an efficient method for the synthesis of first representatives of β-azahetaryl-β-diphenylphosphorylalkanones

Autor: E. I. Goryunov, Polina S. Protopopova, M. A. Galkina, Konstantin A. Kochetkov, I. B. Goryunova, Valery K. Brel, A. B. Uryupin, T. T. Vasil'eva, G. V. Bodrin, A. E. Saifutiarova, Asmik A. Ambartsumyan
Rok vydání: 2016
Předmět:
Zdroj: Russian Chemical Bulletin. 65:1855-1858
ISSN: 1573-9171
1066-5285
Popis: Aza-Michael reaction of (E)-4-(diphenylphosphoryl)but-3-en-2-one (1) with a number of mono-and bicyclic nitrogen heterocycles proceeds regioselectively in the absence of catalysts with the formation of corresponding β-azahetaryl β-diphenylphosphoryl ketones; in the case of imidazole, the presence of chiral organic catalysts allows one to increase the yields of the adducts and to obtain them in enantiomerically enriched form.
Databáze: OpenAIRE