Aza-Michael reaction as an efficient method for the synthesis of first representatives of β-azahetaryl-β-diphenylphosphorylalkanones
Autor: | E. I. Goryunov, Polina S. Protopopova, M. A. Galkina, Konstantin A. Kochetkov, I. B. Goryunova, Valery K. Brel, A. B. Uryupin, T. T. Vasil'eva, G. V. Bodrin, A. E. Saifutiarova, Asmik A. Ambartsumyan |
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Rok vydání: | 2016 |
Předmět: | |
Zdroj: | Russian Chemical Bulletin. 65:1855-1858 |
ISSN: | 1573-9171 1066-5285 |
Popis: | Aza-Michael reaction of (E)-4-(diphenylphosphoryl)but-3-en-2-one (1) with a number of mono-and bicyclic nitrogen heterocycles proceeds regioselectively in the absence of catalysts with the formation of corresponding β-azahetaryl β-diphenylphosphoryl ketones; in the case of imidazole, the presence of chiral organic catalysts allows one to increase the yields of the adducts and to obtain them in enantiomerically enriched form. |
Databáze: | OpenAIRE |
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