Effect of various indolylalkylamines on the motor cells of mollusk embryos and the blood vessels of the rabbit ear

Autor:	G. A. Buznikov, I. V. chudakova, P. G. Zherebchenko
Rok vydání:	1965
Předmět:	Tryptamine medicine.medical_specialty Rabbit (nuclear engineering) Embryo General Medicine Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Endocrinology chemistry Biochemistry Internal medicine medicine Serotonin Motor activity
Zdroj:	Bulletin of Experimental Biology and Medicine. 59:527-531
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00783076
Popis:	All of the studied indolylalkylamines (30 substances in all) as well as β-indazolylethylamine are capable of stimulating the embryonal motor activity of nudibranchiate mollusks. The most active in this respect is 5-hydroxytryptamine (serotonin). Combinations with substituting groups in the 2nd, 4th, 6th, or 7th position of the idol ring are less active than tryptamine. the activity is also lessened by elongation of the lateral chain (δ-3-indolylbutylamine), by inclusion of the methyl group in the α-position or by substituting nitrogen for carbon in the 2nd position of the inactive. With the formation of innervation the sensitivity of the motor cells to serotonin and tryptamine declines and to a number of other indolylalkylamine increases. A similar series of activities has been discovered in the study of the vasoconstrictive effect of indolylalkylamine on the vessels of the rabbit eat.
Databáze:	OpenAIRE
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