Differential Assembly of GPCR Signaling Complexes Determines Signaling Specificity
| Autor: | Abla Benleulmi-Chaachoua, Ralf Jockers, Pascal Maurice |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
Chemistry Context (language use) Subcellular localization Cell biology Transport protein 03 medical and health sciences 0302 clinical medicine Proteome Extracellular Signal transduction Receptor 030217 neurology & neurosurgery 030304 developmental biology G protein-coupled receptor |
| Zdroj: | Subcellular Biochemistry ISBN: 9789400747647 |
| Popis: | Recent proteomic and biochemical evidence indicates that cellular -signaling is organized in protein modules. G protein-coupled receptors (GPCRs) are privileged entry points for extracellular signals that are transmitted through the plasma membrane into the cell. The adequate cellular response and signaling specificity is regulated by GPCR-associated protein modules. The composition of these modules is dynamic and might depend on receptor stimulation, the proteome of a given cellular context, the subcellular localization of receptor-associated modules, the formation of GPCR oligomers and the variation of expression levels of components of these modules under physiological, for example circadian rhythm, or pathological conditions. The current article will highlight the importance of GPCR-associated protein modules as a biochemical basis for signaling specificity. |
| Databáze: | OpenAIRE |
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