Synthesis of poly(ether esters) from reaction of alpha-cyano-4-hydroxycinnamic acid and group IVB metallocenes
| Autor: | Kendra Black, Michael R. Roner, Marian Ayoub, Alisa Moric-Johnson, Lindsey Miller, Ryan Crichton, Charles E. Carraher |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Materials science Polymers and Plastics Infrared spectroscopy Ether 02 engineering and technology General Chemistry alpha-Cyano-4-hydroxycinnamic acid Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Interfacial polymerization 0104 chemical sciences law.invention chemistry.chemical_compound Magazine chemistry law Yield (chemistry) Polymer chemistry Materials Chemistry Ceramics and Composites Moiety 0210 nano-technology |
| Zdroj: | Journal of Macromolecular Science, Part A. 53:328-334 |
| ISSN: | 1520-5738 1060-1325 |
| DOI: | 10.1080/10601325.2016.1165993 |
| Popis: | Poly(ether esters) are rapidly synthesized in moderate yield employing the interfacial polycondensation reaction system from the reaction of alpha-cyano-4-hydroxycinnamic acid and Group IVB metallocenes. The products are high polymers. Infrared spectroscopy shows the formation of new bands derived from the M-O and M-O(CO) linkages. It also shows that the products exist as alternating M-O and M-O(CO) linkages. The products show outstanding inhibition of a variety of cancer cell lines including two pancreatic cancer cell lines. EC50 values for the polymers are in the nanogram/mL range. The ability to inhibit the cancer cell lines is generally Hf>Zr>Ti. Thus, future synthesis and testing might consider using compounds containing hafnocene and zirconocene in addition to the titanocene moiety. |
| Databáze: | OpenAIRE |
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