| Autor: |
Doug Hughes, Scott Y. Rahimi |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Tumors of the Central Nervous system, Volume 3 ISBN: 9789400713987 |
| DOI: |
10.1007/978-94-007-1399-4_35 |
| Popis: |
Postoperative pain management in neurosurgical patients is a complex issue. Patients undergoing craniotomies have traditionally received opiates for the management of their postoperative pain. This limited approach to craniotomy pain issues yields results that are limited by the specificity of the opiate class. Additionally, opiate receptors lack specificity within the central nervous system. This results in the undesirable side effect of CNS depression which limits the dosing a patient can receive. Our elaborate pain pathway is a system that has been thoroughly studied and described in the literature. The Gate Control Theory, introduced by Melzak and Wall, was the first widely accepted pain theory. Our current understanding of the pain pathway also acknowledges a central modulation of pain primarily from the thalamus and the periaquductal gray. As our understanding of the complexity of the pain pathway has evolved, new medications such as cyclooxygenase-2 inhibitors and Tramadol have been utilized to more specifically modulate the pain pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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