Effect of Thiamine Nutritional Deficiency on the Energy Metabolism and Neurotransmission in Mice Brain

Autor:	Anisha Chauhan, Parvesh Bubber, Nidhi Srivastva
Rok vydání:	2017
Předmět:	chemistry.chemical_classification medicine.medical_specialty Succinate dehydrogenase Metabolism Biology Malate dehydrogenase Citric acid cycle chemistry.chemical_compound Enzyme Endocrinology chemistry Fumarase Internal medicine medicine biology.protein Thiamine Neurotransmitter
Zdroj:	The Indian Journal of Nutrition and Dietetics. 54:414
ISSN:	2348-621X 0022-3174
DOI:	10.21048/ijnd.2017.54.4.16198
Popis:	Thiamine or vitamin B1 has an antioxidant property. It plays a vital role in energy metabolism as it is directly or indirectly involved in the metabolism of lipids, glucose, amino acids and neurotransmitters. Present study emphasizes the role of thiamine deficiency (TD) on the mitochondrial enzymes involved in energy metabolism and neurotransmission. The study was carried out on Mus musculus in three groups, namely control and thiamine-deficient group for 8 (TD 8, group II) and 10 (TD 10, group III) days. Activity of TCA cycle enzymes such as succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and fumarase were measured along with the activity of enzyme acetylcholine esterase (Ach E) involved in the release of neurotransmitter. These biochemical changes were further correlated with histopathological changes in TD. A significant decrease in the enzymatic activity of SDH was found in group II (pp
Databáze:	OpenAIRE
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