One-pot synthesis of cerium doped 3D ZnO nano-flowers modified on glassy carbon electrode as portable electro-chemical sensing platform for sensitive detection of methotrexate as an anticancer drug
| Autor: | Shohreh Jahani, Mohammad Mehdi Foroughi, Maryam Kazemipour, Fariba Borhani, Amin Faridi Abbas abad, Khatereh Mohammadi, Nezhat Jandaghi |
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| Rok vydání: | 2019 |
| Předmět: |
Detection limit
Materials science Mechanical Engineering technology industry and agriculture Metals and Alloys chemistry.chemical_element 02 engineering and technology Chronoamperometry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Electronic Optical and Magnetic Materials Catalysis Cerium Chemical engineering chemistry Mechanics of Materials Nano Electrode Materials Chemistry Differential pulse voltammetry Cyclic voltammetry 0210 nano-technology |
| Zdroj: | Synthetic Metals. 256:116119 |
| ISSN: | 0379-6779 |
| DOI: | 10.1016/j.synthmet.2019.116119 |
| Popis: | Ce-doped ZnO catalysts were synthesized for the first time with simplistic hydrothermal method and characterized by XRD, SEM and EDX. The impact of cerium amount (0, 6 and 12%) on the structure and morphology of Ce-doped ZnO catalyst was investigated. According to the findings, the as-synthesized Ce-doped ZnO has nano-flower structures, big pore volumes and high surface area. In addition, an electro-chemical sensor has been constructed based on Ce-doped ZnO nano-flowers modified-glassy carbon electrode. Electro-chemical detection of methotrexate that is used as an anticancer medicine is conducted by the modified electrode. Electro-chemical methods for examining electro-chemical behaviors of methotrexate on the modified electrode surfaces have been chronoamperometry, cyclic voltammetry, and differential pulse voltammetry. This research findings demonstrated the synergetic impact of Ce-doped ZnO nano-flowers on the oxidation of methotrexate via declining oxidation over-potential and enhancing oxidation peak current. When instrumental and experimental conditions have been optimized, the suggested electro-chemical sensor has been used to measure methotrexate in the range between 0.01–500.0 μM with a detection limit of 6.3 nM. Sensitiveness and functionality of the suggested electro-chemical sensor toward methotrexate have been explored by analyzing pharmaceutical ampoules, which was accompanied by acceptable outcomes. |
| Databáze: | OpenAIRE |
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