Molecular mechanisms of vasoconstrictor action of imidazo[1,2-α]benzimidazole derivative RU-117 possessing local anesthetic properties
| Autor: | Kh. P. Takhchidi, B. E. Malyugin, A. S. Dukhanin, A. P. Galenko-Yaroshevskii |
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| Rok vydání: | 2007 |
| Předmět: |
Agonist
Calcium metabolism medicine.medical_specialty Chemistry medicine.drug_class chemistry.chemical_element Eprosartan General Medicine Calcium Angiotensin II General Biochemistry Genetics and Molecular Biology Endocrinology Irbesartan Internal medicine cardiovascular system Prazosin medicine Endothelin receptor medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 143:595-597 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-007-0190-z |
| Popis: | We studied the mechanisms of action of imidazobenzimidazole derivative RU-1117 on calcium homeostasis in myocytes isolated from rat thoracic aorta. In therapeutic concentrations, RU-1117 increased the content of free calcium ions due to their mobilization from intracellular depot via the IP3-dependent mechanisms. Antagonists of angiotensin II AT1-receptors irbesartan and, to greater extent, eprosartan abolished the calcium-mobilizing action of RU-1117. Selective antagonist of endothelin ETA-receptors sitaxsentan and α1-adrenoceptor agonist prazosin produced no effect on calcium mobilization caused by novel local anesthetic RU-1117. |
| Databáze: | OpenAIRE |
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