The Role of Reticulocyte Hemoglobin Content in the Management of Iron Deficiency Anemia in Patients on Hemodialysis
| Autor: | Rizna Abdul Cader, Kong Wei Yen, Abdul Halim Abdul Gafor, Ravih Subramaniam, Firdaus Hadi, Shamsul Azhar Shah, Rozita Mohd |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Randomization biology business.industry Transferrin saturation Urology medicine.medical_treatment 030232 urology & nephrology medicine.disease Gastroenterology Group B law.invention Ferritin 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Iron-deficiency anemia law Internal medicine biology.protein Medicine Hemoglobin Hemodialysis business 030215 immunology |
| Zdroj: | Nephro-Urology Monthly. 10 |
| ISSN: | 2251-7014 2251-7006 |
| Popis: | Background: The objectives of this study were to correlate reticulocyte Hemoglobin Content (CHr) with Hemoglobin (Hb), ferritin, and Transferrin Saturation (TSAT) in Patients on Hemodialysis (HD) and to determine the Hb response with intravenous iron supplementation in anemic HD patients with adequate ferritin and TSAT yet low CHr. Methods: This was a prospective, randomized controlled trial involving patients on HD. Patients with baseline results that fulfilled the randomization criteria (CHr 400 ng/mL and/or TSAT > 20%) were then randomized to group A and B. Group A patients received a total of 1 g of intravenous iron and group B served as the control. Results: One hundred and twenty - one patients were enrolled in this study. There was a significant correlation between CHr and TSAT, ferritin, and Hb. A total of 12 patients were randomized to group A and B. There was a significant increase in Hb level observed in group A with median change from baseline of 1g/dL (IQR: - 0.5 to 2.8) at the end of the trial compared to the control group. Conclusions: There was a significant correlation between CHr, Hb, ferritin, and TSAT. Intravenous iron supplement improved Hb level in patients on HD with adequate serum ferritin and/or TSAT levels yet low CHr. |
| Databáze: | OpenAIRE |
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