| Autor: | Françoise Chanussot, C. De La Maisonneuve, Lambert R, Benkoel L, Dodero F, Chamlian A, Brisse J |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
food.ingredient biology Physiology ATPase Sodium Immunocytochemistry Gastroenterology food and beverages chemistry.chemical_element medicine.disease digestive system Lecithin Staining Endocrinology food Cholestasis chemistry Internal medicine polycyclic compounds medicine biology.protein lipids (amino acids peptides and proteins) Liver function Na+/K+-ATPase |
| Zdroj: | Digestive Diseases and Sciences. 44:1643-1649 |
| ISSN: | 0163-2116 |
| DOI: | 10.1023/a:1026683531461 |
| Popis: | We studied the effect of dietary soybean lecithin or triacylglycerol on hepatic Na+,K(+)-ATPase in cyclosporine A-treated rats by means of quantitative immunocytochemistry. Cyclosporine A-treated rats were fed lecithin or a triacylglycerol-enriched diet or a low-fat diet. As a control, one group was only fed the low-fat diet; the three other groups were treated with cyclosporine A solvent and received the low fat, lecithin, or triacylglycerol diet. Bile canalicular staining significantly decreased in all cyclosporine A-treated groups with the higher values in lecithin-fed rats. In basolateral membranes, no decrease was observed in the lecithin-cyclosporine group, in contrast to the other groups. The triacylglycerol-cyclosporine group had lower values in both membrane domains. The alteration of Na+,K(+)-ATPase by cyclosporine A was related to cholestasis evidenced by a decrease in bile salt secretion. These modifications were prevented by dietary soybean lecithin and amplified by dietary soybean triacylglycerol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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